Stoichiometric Inhibition of Reduced Xanthine Oxidase by Hydroxypyrazolo[3,4-d]pyrimidines
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چکیده
منابع مشابه
Stoichiometric Inhibition of Reduced Xanthine Oxidase
The inhibition of reduced bovine milk xanthine oxidase by 4 hyd.roxypyrazolo[J ,4 dlpyrimidine (4 HPP) and 4,6dihydroxypyrazolo[3,4 d]pyrimidine (4,6 diHPP) is “stoichiometric” or “titrating” in type, i.e. the inhibition is virtually complete ( >90%) at concentrations of inhibitor equimolar with that of the enzyme. The dissociation constant of the reduced enzyme-4,6-diHPP complex, determined by...
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Various dietary flavonoids were evaluated in vitro for their inhibitory effect on xanthine oxidase, which has been implicated in oxidative injury to tissue by ischemia-reperfusion. Xanthine oxidase activity was determined by directly measuring uric acid formation by HPLC. The structure-activity relationship revealed that the planar flavones and flavonols with a 7-hydroxyl group such as chrysin,...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1970
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62820-0